Search on: 2-ISOPROPYLMALATE SYNTHASE 
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Descriptor English:   2-Isopropylmalate Synthase 
Descriptor Spanish:   2-Isopropilmalato Sintasa 
Descriptor Portuguese:   2-Isopropilmalato Sintase 
Tree Number:   D08.811.913.050.614
Definition English:   An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12. 
History Note English:   91(75); was see under KETOACID-LYASES 1975-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   7712 
Unique Identifier:   D015079 

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